Zurich, the city
My adventures so far in the Canton of Zurich have been confined only to the city of Zurich, which is the largest city in Switzerland. I went to Zurich back in 2016. I was doing an internship in Freiburg im Breisgau with two friends from the US visiting me. Since Zurich was close and we could get there using Flixbus, we went! We had an amazing time there. If you click on the point on the map, you can read all about the city.
I would definitely recommend a visit to the city. Warning: Switzerland is an expensive place and the city is even more so. It is the financial/banking capital and has one of the most expensive shopping streets in the world. Lots of people go and through around a lot of money here, so the prices of many things reflect that as well.
Depending on what you would like to see in the city, I would recommend spending a weekend here. It is not so massive that you need tonnes of time but it is larger than other European cities, so spending time here is a good idea. In addition to hotels, you should check local AirBnBs and couch surfing for cheaper options.
In addition to the bus, you can also drive (naturally) or fly here. The airport is north of the city and there are direct trains to the city centre. You can also rent a car or take a taxi or local bus from the airport to various locations around the city.